Down-on-their luck brothers Lars and Ernie Smuntz (Nathan Lane and Lee Evans) don't think much of the crumbling old mansion they inherit...until they discover that their dilapidated estate is actually worth millions. But before they can cash in, they've got to rid the house of its single, stubborn occupant: a tiny and tenacious mouse. What might seem like child's play becomes an epic battle of hysterical proportions.