When Dr. Peter Venkman and his Columbia University colleagues are kicked out of their prestigious academic posts they start a private practice as professional ghost-catchers. Although the three parascientists are idle for awhile their television advertisements finally pay off when beautiful Dana Barrett contracts them. It seems her apartment has become the entryway for ghastly ghosts and goofy ghouls hellbent on terrorising New York City. Soon theyre going to her rescue trying to rid the city of the slimy creatures.