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London-based military intelligence officer Colonel Katherine Powell (Helen Mirren) is remotely commanding a top secret drone operation to capture a group of dangerous terrorists from their safe-house in Nairobi, Kenya. The mission suddenly escalates from a “capture” to a “kill” operation as Powell realizes that the terrorists are about to embark on a deadly suicide mission. From his base in Nevada, American drone pilot Steve Watts (Aaron Paul) is poised to destroy the safe-house when a nine year old girl enters the kill zone just outside the walls of the house. With unforeseen collateral damage now entering the equation, the impossible decision of when to strike gets passed up the “kill chain” of politicians and lawyers as the seconds tick down.